The lowest estimate was derived using population upper levels of normal and the highest estimate was derived using the mean GFR of the community children (137 mL/min per 1.73m 2) to back-calculate the bSCr. Using the different bSCr estimates, we demonstrated the prevalence of KDIGO-defined AKI in children with severe malaria ranged from 15.6-43.4%. The Pottel-age based equation, assuming a normal GFR of 120 mL/min per 1.73m 2, was the more accurate method with minimal bias when compared to the Schwartz height-based equation. We compared methods to estimate bSCr in healthy community children against the IDMS-traceable SCr measure. Using isotope dilution mass spectrometry (IDMS)-traceable creatinine measures from community children, we evaluated the bias, accuracy and precision of estimating bSCr using height-dependent and height-independent estimated glomerular filtration (eGFR) equations to back-calculate bSCr or estimating bSCr directly using published or population-specific norms. We evaluated six methods to estimate bSCr in Ugandan children aged 6 months to 12 years of age in two cohorts of children with severe malaria (n = 1078) and healthy community children (n = 289). Prior to wide-spread utilization, bSCr estimation methods need to be evaluated in many populations, particularly in children from low-income countries. ![]() However, approaches to estimate baseline creatinine (bSCr) are not standardized in this unique patient population. kidney injury (AKI) is increasingly recognized as a consequential clinical complication in children with severe malaria. Walnut St., Indianapolis, IN, 46202, USA.
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